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McMaster University

Brockhouse Institute Seminar

SPEAKER Melanie CW Campbell, PhD, FOSA, FInstPhys, Professor and Director, Graduate Studies in Physics, University of Waterloo
TOPIC Diagnostic Imaging in the Eye and through the Eye, the Brain 

We have developed novel methods which give improved images of the retina. We can see normal structures more clearly as well as structural changes associated with disease. We use fluorescence, adaptive optics and imaging with polarised light to diagnose conditions (as diverse as cone photoreceptor dysfunction, malaria and Alzheimer’s disease) and to understand underlying mechanisms of disease. In a powerful approach to diagnosing diseases of the brain, we use the fact that the blood supply and neural cells in the retina share many similarities with those in the brain. We were among the first to show that amyloid, present in the brain in association with Alzheimer’s disease is also present in the retina. More recently we have shown that the number of amyloid deposits in the retina is correlated with the severity of the disease, assessed after death.

Following a CSIRO Fellowship in Canberra, Australia Melanie Campbell returned to Canada on a NSERC University Research Fellowship. Prof. Campbell studies eye development, eye disease and linear and nonlinear optics of the eye. Campbell is known for her work on the gradient index optics of the crystalline lens, its changes with ageing and visual experience. She has discovered optical signals to eye growth which follow a circadian rhythm. She collaborated in the first real-time images of the cone photoreceptors of the eye, using adaptive optics. Imaging applications of interest include the biomarkers of Alzheimer’s disease, using the retina as a window on the brain.

Campbell is a Fellow of the Optical Society of America and a former member of OSA’s Board of Directors, a Fellow of the Institute of Physics (UK), and a former President of the Canadian Association of Physicists. Campbell was a co-founder of Biomedical Photometrics Inc, now Huron Technologies. Campbell shared the 2004 Rank Prize in Optoelectronics for her work cited as "an initial idea (that) has been carried through to practical applications that have, or will, demonstrably benefit mankind." In 2014, she was awarded the CAP INO Medal for Outstanding Achievement in Applied Photonics. In 2015, she was awarded the OCUFA Status of Women Award of Distinction for her work to improve the position of academic women through organizational, policy, and educational leadership.

DATE Monday, March 13, 2017
TIME 3:30 pm

For more information phone 905-529-7070 X24559 or Email the Department of Physics and Astronomy

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